Abstract
Chloromethyl-methylisothiazolone (CMIT/MIT) is a broad spectrum biocide which has been used successfully for microbial control and preventing biofouling in industrial water treatment. This paper presents a review of the various reports over the past 20 years on the efficacy of CMIT/MIT biocide versus Legionella bacteria and the protozoa associated with their growth. These studies included a wide range of conditions, including single organisms in cooling water and complex model systems with bacteria, biofilms, and protozoa. Overall, low levels of CMIT/MIT (1-10 ppm active) provided significant reduction in viable counts of various strains and species of Legionella bacteria in planktonic and biofilm studies and also against the amoebae and ciliated protozoa associated with their growth.