Abstract
Rouging is a well-known but poorly understood phenomenon in the pharmaceutical industry. It involves formation of red-brown to dark violet iron deposits on the inside surface of distillation columns, storage vessels and distribution systems for hot WFI (Water For Injection). The affected systems are made from stainless steel type AISI 316L as the primary construction material. The paper describes several cases of rouging in WFI systems as to characteristics and distribution. Field observations are correlated with published literature and experimental data obtained in the laboratory. Finally, theories of the mechanism as well as approaches to preventing rouge are discussed.
© 2007 Association for Materials Protection and Performance (AMPP). All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means (electronic, mechanical, photocopying, recording, or otherwise) without the prior written permission of AMPP. Positions and opinions advanced in this work are those of the author(s) and not necessarily those of AMPP. Responsibility for the content of the work lies solely with the author(s).
2007
Association for Materials Protection and Performance (AMPP)
You do not currently have access to this content.
